Excessive amounts of body fat, especially stored in and around the abdomen, release adipokines. These mediators are known as cytokines or adipokines (ones from fat)
These are a broad category of proteins secreted by one cell and then affecting other cells (through a signaling cascade). Many adipokines increase inflammation in our body. Others impact cells producing different cytokines and lead to a cascade of signals causing insulin resistance, auto-immune disease, osteoarthritis, vascular disease, cancers, premature aging and death.
Cancers risks associated with Obesity include:
Bladder, Brain, Breast, Cervical, Colon, Uterine, Esophageal,
Gallbladder, Head & Neck, Kidney, Leukemia, Liver, Multiple Myeloma
Non-Hodgkin’s Lymphoma, Ovarian, Prostate, Pancreatic, Stomach, and Thyroid.
More fat cells = more adipokines = more damage.
Lowering your percent body fat is vital to lifelong health.
For further information or further understanding of these factors here are a couple of links