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Anti-Obesity Medicines-What are they?

“Anti-obesity” medications–previously known as weight loss medications–send signals to your brain, changing your hunger, fullness, cravings, and other eating behaviors.

The newest are biological protein molecules that affect gastrointestinal neurohormonal messengers.

The latest Tirzepatide (Mounjaro) affects two gut hormones and shows excellent weight loss results in the research trials. (Not yet approved as an anti-obesity medication, only approved for Diabetes at this time.)

The two others Semaglutide (Wegovy), and Liraglutide (Saxenda), are Glucagon-like-protein-1 receptor agonists (GLP-1 RA’s). They decrease your food intake and improve the metabolism of your food into energy instead of fat.  You get full much faster, stay full longer, and have less hunger; these effects are more pronounced than the older medications.

Phentermine (Adipex), Phendimetrazine (Bontril), and Diethylpropion (Tenuate) are medications that decrease hunger, and you get full faster. It may increase your metabolism.

Topiramate (Topamax) and  Zonisamide (Zonegran) are seizure-controlling medications that decrease appetite, change your taste for some foods, and often significantly reduce food urges (Cravings/Binge Eating)

Bupropion and Naltrexone combination (Contrave) helps you get full faster.  It decreases emotional eating. It increases your energy and your mood.  And it blocks some of that “I need a brownie because it has been a bad day” eating.

If you do not want any “medications,” consider these two gastrointestinal-only treatments.

A new medication/device is Plenity.  You take three capsules of this specially designed natural fiber. It is taken twice daily, 20 minutes before meals, with at least 16 ounces of water.  The capsules open and expand in your stomach with a safe dissolvable fiber.  The decreased room in your stomach helps you get full faster and blocks the amount you can eat.

Orlistat (Xenical or Alli) is a fat blocker that works in your gut.  It binds up part of your meal’s fat and decreases the calories you absorb.

Please keep in mind that all medications have side effects and interactions; please consult your medical provider about these properties before starting any of these medications.